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Aims: To evaluate the antimalarial activity of the aqueous (KGA) and n-hexane (KGN)extracts of the stem bark of Khaya grandifoliola (Meliaceae) in combination withartemisinin (ART) in mice.Study Design: Preclinical antimalarial assessment in mice subjects.Place and Duration of Study: Biological Laboratory, Drug Research and ProductionUnit, Obafemi Awolowo University, Ile-Ife between November 2006 and September 2007.Methodology: In the first phase, 65 mice inoculated intraperitoneally with Plasmodiumberghei were divided into groups of five mice each. Oral administration of KGA and KGN(50-400 mg/kg each) and artemisinin (0.2-1.6 mg/kg) was done for four days starting onthe day of inoculation in the 4-day antimalarial test model. Giemsa-stained thin bloodsmear, from the tail of each mouse, was microscopically assessed for the parasitized andtotal number of red blood cells of ten fields. The combinations of the sub - effective dosesof each of KGA and KGN (100 mg/kg) with ART (0.2 mg/kg) were similarly evaluated andassessed.Results: The median effective doses (ED50) were 0.29, 140 and 160 mg/kg forArtemisinin, KGA and KGN, respectively. The combinations (KGA: ART and KGN: ART)resulted in improved parasitemia suppression which were statistically significant (P = .05)when compared with the percentage parasitaemia obtained for individual agents of thecombinations.Conclusion: Extracts of K. grandifoliola potentiated the antimalarial activity ofArtemisinin. The results showed beneficial interaction with potentials in antimalarialcombination therapy

In vivo Interaction between Extracts of Khaya grandifoliola (Welw) CDC (Meliaceae) and Artemisinin in a Murine Malarial Model