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Aim: Ethanolic extracts of Kigelia africana, Nauclea latifolia and Staudtia stipitata wereinvestigated for their phytochemical constituents and antiulcerogenic potential on aspirininduced ulcer in albino rats at 150mg/kg, 300mg/kg, and 450mg/kg body weights.Place and Duration of Study: The study was carried out at Department of Biochemistry,Adekunle Ajasin University, Akungba-Akoko, Ondo State, Nigeria, between June 2009and August 2010.Methodology: Ulcer was induced by administering aspirin (200mg/kg body weight) orallyto albino rats. Phytochemical screening of leaf extracts was done using standard methodsafter ethanolic extraction had been concluded. Biochemical parameters showing theeffects of ethanolic extracts of the different leaves used in treating ulcer were tested usingstandard methods.Result: The extracts gave positive results to saponin, tannins, phylobatannins,anthraquinones and cardiac glycosides. K. africana at a concentration of 450 mg/kg bodyweight gave the best results with a significant decrease in ulcer index (0.67±0.16) on aspirin-induced ulcerogenic animals compared to 3.0 for the reference drug (Cimetidine at300mg/kg) and control with 1.67±0.27, while the leaf extracts of S. stipitata showed theleast efficacy.Conclusion: This study contributes to the search for potent and locally available plantmaterials for managing ulcer disease caused by non-steroidal antiinflammatory drugs

Antiulcerogenic Activity of Kigelia africana, Nauclea latifolia and Staudtia stipitata on Induce Ulcer in Albino Rats