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The use of plants and their derived substances increases day by day for the discovery ofnew therapeutic agents owing to their versatile applications. Conocarpus erectus L. (familyCombretaceae) is one of two species in the genus Conocarpus widely spread in Taif andother parts of the Kingdom of Saudi Arabia. It is used in some countries as folk remedy foranemia, catarrh, conjunctivitis, diabetes, diarrhea and fever. To our knowledge fromliteratures there is little work about phytochemical contents and biological activities of C.erectus which encouraged the authors to carry out this study. The four defatted methanolextracts of C. erectus different parts (leaves, stems, fruits and flowers) showed high freeradical scavenging activity toward DPPH radical with SC50 between 6.47-9.4 μg/ml. The n-BuOH fractions obtained from successive fractionation of the four defatted methanolextracts had radical scavenging activity with SC50 between 4.43-5.89 μg/ml higher than theEtOAc fractions (7.04-10.71 μg/ml). Due to the high antioxidant activity of the EtOAc andn-BuOH fractions, it was in vitro assayed toward two human cancer cell lines; HepG2 &MCF-7; using Sulphorhodamine-B assay method. The results showed that most fractionshad cytotoxic activity with IC50< 20μg/ml which fall within the American Cancer Institutecriteria. A preliminary antibacterial screening of the four defatted methanol extracts of thedifferent parts toward five bacterial strains were done. Phytochemical investigation of the EtOAc and n-BuOH fractions showed that phenolic compounds constitute the majorcomponents of it. In conclusion this is the first report on the phytochemical and biologicalproperties of Conocarpus erectus growing in Taif governorate, KSA. More in vivo and invitro studies along with detailed phytochemical investigation are needed in the hope to canuse this plant (crude extract, fractions, sub-fractions or pure compounds) in the preventionand therapies of some diseases

Phytochemical Studies and Evaluation of Antioxidant, Anticancer and Antimicrobial Properties of Conocarpus erectus L. Growing in Taif, Saudi Arabia