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Objective: Seven to eight days germinated plants of Triticum aestivum (wheat grass) area rich source of vitamin A, C, calcium, magnesium, phosphorus, potassium, sodium,sulphur, cobalt, zinc and protein. Traditionally the aqueous extract of T. aestivum wasreported to be used as a health tonic in folk and ayurvedic medicine. We previouslyreported that aqueous extract of T. aestivum was found to reduce the blood transfusionrequirement in iron overloaded Thalassemia and Myelodysplastic syndrome patients. Ourobjective was to extract and purify active ingredients from wheat grass and study theirmode of action in stabilizing hemoglobin level in those patients.Design and Method: Active ingredients of wheat grass were extracted and purified bycation exchange column chromatography followed by High Performance LiquidChromatography. In vitro experiments with phenylhydrazine treated red blood cellhemolysate were carried out before and after treatment of purified fraction of T. aestivumto study iron chelating activity.Result: Purified fraction of T. aestivum treated red blood cell showed significant inhibition of free reactive iron production and formation of thio-barbituric acid reactive substanceswhen compared to desferrioxamine treated hemolysate.Conclusion: Iron chelating activity of purified fraction of T. aestivum, an inexpensive,easily available source, is very promising for further clinical trial and development of oraliron chelator drug for Thalassemia, Myelodysplastic syndrome and other iron overloadeddiseases

In vitro Studies of Iron Chelation Activity of Purified Active Ingredients Extracted from Triticum aestivum Linn. (Wheat Grass)