English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Aims: To investigate seasonal variation in anti-diabetic and hypolipidemic activities ofMomordica charantia fruits harvested at different seasons of the year, namely spring,summer, autumn and winter.Methodology: Air-dried and pulverized fruit samples were extracted by soaking in 70%methanol for 72h. The filtrate was concentrated using rotary evaporator. The yields ofspring (MME), summer (JME), autumn (SME) and winter (DME) samples were 8.4, 7.1,4.8 and 5.1% respectively. For each of the four fruit samples, rats were divided into sixgroups of six rats each. First group served as normal control (non-diabetic). Theremaining five groups were made diabetic by administering alloxan (120mg/kg bodyweight) intraperitoneally. Second group served as diabetic control. Third, fourth and fifthgroups were treated with oral doses of 200, 400 and 600mg/kg body weight of Momordicacharantia fruit extracts respectively. The sixth group received oral dose of glibenclamide(5mg/kg body weight) which served as the standard drug. These treatments wererepeated daily for 28 days.Results: Treatment with methanol extracts of Momordica charantia caused a significant(p<0.01) and dose-dependent changes with respect to blood glucose level and lipid profilein all the four samples, when compared with the untreated animals. The highest activitywas observed with spring sample, followed by the summer sample. Autumn and wintersamples have more or less similar but lesser effects than summer sample.Conclusion: The results of this study showed that anti-diabetic and hypolipidemic effectsof Momordica charantia fruit extract vary during different seasons of the year. The springsample produced the highest activity. This suggests that the active principles inMomordica charantia fruit that are responsible for its antidiabetic and hypolipidemic activity vary in quantity and/or quality during different seasons of the year and reach thepeak during spring

Seasonal Variation in the Anti-Diabetic and Hypolipidemic Effects of Momordica charantia Fruit Extract in Rats