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Oral conditions that produce the greatest damage on individuals are cavities andperiodontal disease, hence non-expensive and effective solutions are immediatelyrequired, particularly for communities with no access to dental services. Theantimicrobial and anti-inflammatory potential of the Swedish bitter herbal extract wasevaluated, using pure microbial cultures and clinical samples of 29 patients. It wasobserved that the extract caused significant (p<0.05) in vitro growth inhibition of up to29%, 17%, 15%, and 50% against Prevotella intermedia, Bacteroides forsythus,Porphyromonas gingivalis and Streptococcus intermedius, respectively. In addition, theextract significantly (p<0.05) inhibited oral flora growth in patient samples showing MICsof < 7.8 μg/ml in 21% of the patients, 15.6μg/ml in 17% of the patients, 31.2 μg/ml in10% of the patients, 62.5 μg/ml in 17% of the patients, 125 μg/ml in 3% of the patients,and 250 μg/ml in 7% of the patients, and induced a maximum of 75% growth inhibition,as measured by the MTT reduction assay. The extract was also observed to significantlysuppress production of the inflammatory marker nitric oxide by LPS-treated murineperitoneal macrophages. The Swedish herbal extract may be considered in the clinics to prevent or treat bacterial oral infections and at the same time reducing inflammation

Antimicrobial and Antiinflammatory Potential of the Swedish Herbs Extract