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and objectives: [ 99mTc] Tc-HMPAO, developed for brain imaging, is taken up by the heart, but never used to study it.  We aimed to compare cardiac images with [99mTc] Tc-HMPAO and [ 99mTc] Tc-Tetrofosmin, using imaging techniques.  Materials and methods: Cardiac gated SPECTs with [99mTc] Tc-HMPAO were compared with myocardial perfusion scintigraphies (MPS) with [99mTc] Tc-Tetrofosmin in three inpatients, from the vascular surgery ward.  We developed algorithms in MATLAB R2016 to compare the [99mTc] Tc-Tetrofosmin/ [99mTc] Tc-HMPAO images. Pixel-wise correlations for slices, reversibility, and polar maps were obtained.  Results: Correlations of both radiotracers’ myocardial images were as high as 0.93. Polar maps correlations were 0.93-0.95 (for both stress and rest) and 0.62-0.90 (reversibility).  One of the patients (smoker) had significant lung [99mTc] Tc-HMPAO uptake.  Conclusions: Cardiac SPECT with [99mTc] Tc-HMPAO might be a screening method for myocardial ischemia in non-smoking patients with epilepsy suspected of having heart changes, and who need to perform a brain perfusion SPECT.  Keywords: myocardial perfusion scintigraphy; epilepsy; HMPAO; myocardial SPECT.

Imaging myocardial perfusion with [99mTc] Tc-HMPAO: Fiction or reality? – Preliminary results