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This study evaluated the potential of biogas generation of the fresh organic fraction of municipal solid wastes (OFMSW) inoculated with swine manure and cattle manure, based on the volatile solids content obtained from biochemical methane potential (BMP) tests. Several physico-chemical parameters (e.g. volatile solids, pH and chemical oxygen demand) were assessed in the laboratory before and after 50 days of incubation of several samples of OFMSW, swine manure and cattle manure, and mixtures thereof. During incubation, reductions in percentage of volatile solids were relatively low (from 5.5% to 11.4%), indicating the existence of substrates that can degrade after the 50-day digestion period. Among the physico-chemical parameters evaluated, pH was a limiting parameter for anaerobic digestion of OFMSW and manures. The mixture showing the best performance in terms of volume of biogas generated contained 1 gvs OFMSW: 1 gvs swine manure, which led to the production of 60.4 mL.gVS or 22 mL.gOFMSW biogas. The values of CH4 concentration increased throughout the incubation period, and the CH4 concentration value peaked at 80% for the mixture 1 gvs OFMSW:1 gvs swine manure. The results obtained indicate the OFMSW and manures can be effectively used for power generation. Barbosa, F.J.L., Cabral, A.R., Capanema, M.A. # and Schirmer, W.N. # (2018). Biogas Generation Potential of Anaerobic Co-Digestion of Municipal Solid Wastes and Livestock Manures. Journal of Solid Waste Technology and Management, 44(3): 248-258. Key-words: Biochemical methane potential (BMP); Co-digestion; Landfill; Methane production; Renewable energy.