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Antifungal effects of a 4-(Diphenylphosphinoyl)-2methyl-4-phenylbuta-2,3-dien-1-ol (PA-2) on pathogenic yeast and fungi had been established. PA-2 (50mg/ml, 25mg/ml, 12.5mg/ml, 6.25mg/ml and 3.125mg/ml) exerted different inhibitory effect on different yeast and fungi cells in vitro. The effects of PA-2 on eukaryotic cells have not been studied yet. The present study was aimed to assess the antifungal activity of PA-2on pathogenic yeast and fungi. Experimental approach: In vitro antifungal test: Aspergillus niger, Penicillium claviforme, Saccharomyces cerevisae, Candida albicans 8673 and Candida glabrata 72 were treated for 24 hours with PA-2(50mg/ml, 25mg/ ml, 12.5mg/ml, 6.25mg/ml and 3.125mg/ml), Fluconazole (150 mg/ml). The antifungal activity was assayed by the goot diffusion method with a digital caliper. Determination of minimum inhibitory concentrations (MICs): The MIC of PA-2, that shows antifungal activity was determined by 2-fold dilution methods and MICs were read in ìg/ml after overnight incubation at 37oC. Determination of Minimum fungal concentration (MFC): The MFC was carried out to check whether the test microbes were killed or only their growth was inhibited. Potato Dextrose Agar (PDA, Oxoid, Hampshire, UK) was prepared and sterilized at 121oC for 15 minutes, the medium was poured into sterile petri dishes and was allowed to cool and solidify. The contents of the MIC in the serial dilution were then subcultured onto the prepared medium, incubation was made at 37oC for 24 h, after which each plate was observed for colony growth. All experiments were performed in triplicate. The lowest concentration of the PA-2 without a colony growth was recorded as the MFC. PA-2 had higher antifungal activity than the tested antibiotic (Fluconazole).

ANTIFUNGAL ACTIVITY OF A PHOSPHORYLATED 3-(α-HYDROXYALKYL) ALLENES ETHANOL EXTRACTS