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SUMMARY Oral squamous cell carcinoma (OSCC) accounts for nearly 50 % of all newly diagnosed cancers in India. In Bulgaria OSCC reaches nearly 75% of malignant tumours in the oral cavity (Ugrinov, 2006). The prognosis of this cancer remains relatively unchanged for the past 30 years, despite advances in diagnosis and management. Salivary analysis holds promise as a non-invasive approach to identify biomarkers for human oral cancer. Salivary levels of immunoglobulins and acute phase proteins may have significant prognostic value in early cancer diagnostics.

SALIVARY COMPONENTS OF TREATED CANCER PATIENTS AND PATIENTS WITH PRECANCEROUS LESIONS