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Article history: Received June 25, 2012 Received in Revised form November 6, 2012 Accepted 6 November 2012 Available online 6 November 2012 A simple and environmentally friendly reaction has been developed for the first time for onepot synthesis of β-amino alcohol derivatives from aromatic phenols, epichlorohydrin and amines by using phase transfer catalysts (PTC) and Aspergillus Oryzae lipase biocatalyst. This method provides access to pharmaceutically relevant products in excellent yields with high regioselectivity. The remarkable catalytic activity and reusability of lipase was possible up to four consecutive cycles. © 2013 Growing Science Ltd. All rights reserved.

Synthesis of β-amino alcohol derivatives from phenols in presence of phase transfer catalyst and lipase biocatalyst