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Background:  In animal models of inflammatory diseases,  Mst1  facilitates the programmed cell death as a novel pro-apoptotic kinase. This research aimed to determine the expression level of  Mst1  gene in a rat model of SCI treated with VPA.Methods:  Severe rat model contusion was used for evaluation of the neuroprotective effect of valproic acid. The BBB test, was performed to determine locomotor functions. H&E staining and TUNEL assay were performed to detect cavity formation and apoptosis, respectively. The mRNA levels of the genes  Mst1 ,  Nrf2 , and  Bcl-2  were evaluated, using quantitative RT-PCR.Results:  The results revealed that  Mst1  gene expression and TUNEL-positive cells in the VPA-treated group were significantly reduced as compared to the untreated group ( p  ≤ 0.05).Conclusion:  Our findings indicate that VPA has therapeutic potential and can be a candidate for the treatment of neurodegenerative disorders and traumatic injury as a promising drug.

Valproic Acid Ameliorates Locomotor Function in the Rat Model of Contusion via Alteration of Mst1, Bcl-2, and Nrf2 Gene Expression