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E-Octadec-7-en-5-ynoic acid was isolated from the chloroform extract of the roots of Capparis zeylanica Linn and its sub-acute toxicity study was carried out on Long Evan’s rats. The compound was administered at a dose of 300 g/rat/day for consecutive14 days. The studies included the gross general observation such as changes of body weight, hematological profiles [total count of Red Blood Cells (RBC) and White Blood Cells (WBC), differential count of WBC, platelet count and Hemoglobin (Hb) %], biochemical parameters of blood [ Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT), Serum Alkaline Phosphatase (SALP), urea , serum bilirubin and serum creatinine] and the histopathology of the heart,liver, kidney, and lung of both control and experimental groups of rats. The body weights of the rats were slightly increased. The changes in hematological and biochemical parameters were statistically not significant. No detectable abnormalities were found in the histopathology of the heart, liver, kidney, and lung in the experimental group of rats following the same dose when compared with the control group of rats. This preliminary study suggests that the isolated compound may be used safely for clinical trial.

Sub-acute toxicity study of a novel compound E-Octadec-7-en-5-ynoic acid from Capparis zeylanica Linn roots