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The article presents findings on macroscopic, morphometric and immunohistochemical studies of the liver of broiler chickens during the experimental infection with a pathogenic strain of infectious bursal disease virus (IBD) and the use of Mitofen. It was found that during the experimental infection of chickens with a pathogenic strain of the IBD virus in the liver of chickens, pathological processes characteristic of metabolic disorders were revealed – granular, fine-droplet fatty and vacuolar dystrophy, as well as cell edema, deformation of the nucleus, the prevalence of stromal processes over cellular ones. When using the antioxidant drug ″Mitofen″, areas with dystrophy of various genesis were noted. The morphometric parameters were characterized by the normalization of the cellular components of the organ under the action of the antigen on the organism. At the same time, the size of hepatocytes increased, there was an increase in the count of binuclear liver cells, and the density of the content of liver cells increased per conditional unit of area. The immunohistochemical study revealed the presence of specific phenotypes of lymphocytes in the liver parenchyma, that indicates the activation of humoral immunity.

HISTOARCHITECTONICS, MORPHOMETRIC AND IMMUNOHISTOCHEMICAL CHANGES IN THE LIVER OF CHICKENS UNDER CONDITIONS OF ANTIGENIC LOAD AND THE USE OF MITOFEN