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Objective: The aim of the study was to compare levels of soluble endothelial receptor (sEPCR) among women with severe preeclampsia, mild preeclampsia and normal pregnancy. Methods: The study was conducted at Ataturk University Faculty of Medicine, Department of Obstetrics and Gynecology between February 2011 and September 2011. Pregnant women aged between 18-40 years who had severe or mild preeclampsia were recruited consecutively for the study. Each group consisted of 30 patients. A total of 30 patients who had normal pregnancy were included in the study as a control group. A blood sample was taken from all patients and sEPCR test was performed. Results: Levels of sEPCR were highest in severe preeclamptic (238±107 ng/ml) and lowest in normal pregnant patients (72±72 ng/ml) (p<0.01). sEPCR level was lower in mild preeclampsia (134±85 ng/ml) than severe preeclampsia (p<0.01 for each comparision). There was a positive correlation between sEPCR with diastolic and systolic hypertension (r=0.263 and r=0.252 respectively). Conclusion: sEPCR is higher in preeclamptic pregnants and its level increases with the severity of the disease.

i̇zmir tepecik eğitim hastanesi dergisi

The comparison of the Levels of Soluble Endothelial Protein C Reseptor in Mild And Severe Preeclamptic Group with Normotensive Group at Third Trimester