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Described for centuries in the horses under the terminology of ‘equine melanotic disease’ and, subsequently recognized in non-equine animal models and in humans, animal-type melanoma, also known as pigmented epithelioid melanocytoma (PEM), is characterized by nodules and fascicles of epithelioid transformed melanocytes with pleomorphic nuclei and striking pigmentation, dendritic cells, numerous melanophages and, sometimes, lymphocytic infiltrate1. Up to day, only small series have been reported in humans and, therefore, its biological behavior remains unclear. Recently, some authors have supported that the tumor follows an indolent clinical course, with very low risk of spread beyond regional lymph nodes2. Given the complexity of the matter, Elder and Murphy proposed a histological categorization of PEM and PEM-like lesions, with distinctive clinicopathological and biologic features3. Herein this entity was highlighted and revisited in brief.

Animal-type melanoma: an unusual variant of human melanoma with prominent pigment synthesis and unpredictable course