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Infectious diseases are still a public health problem in Indonesia. Methicillin Resistant Staphylococcus aureus (MRSA) is one of bacteria causing infections that is a concern because of the nature of resistance to various beta-lactam class of antibiotics. Therefore, it is necessary to find an alternative antibiotic for the treatment of MRSA infections. This study aims to determine the antibacterial activity of jackfruit (Artocarpus heterophyllus Lam.) leaf extract against MRSA by minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) conducted using in-vitro test with broth macrodilution method. Jackfruit (Artocarpus heterophyllus Lam.) leaf extract were used in half serial concentration of 1280 μg/ml to 0,625 μg/ml. MIC of jackfruit leaf extract against MRSA was found at concentration of 320 μg/ml which showed by a clear solution in Brain Heart Infusion media. Meanwhile, MBC value of jackfruit leaf extract against MRSA was found at concentration of 1280 μg/ml showed by the absence of MRSA colony growth Mueller-Hinton agar. From this study showed that jackfruit (Artocarpus heterophyllus Lam.) leaf extract has anti-bacterial activity against MRSA in-vitro.

In Vitro Antibacterial Activity Test of Jackfruit (Artocarpus heterophyllus Lam.) Leaf Extract against Methicillin-Resistant Staphylococcus aureus (MRSA)