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Dengue hemorrhagic fever (DHF) remains a major world health problem particularly in Indonesia caused by dengue virus (DENV) infection. Until now, there is no specific antiviral therapy for DENV and the treatment for its infection is still supportive. The extract of Cynometra ramiflora Linn leaves known for having potencies such as bactericide, analgesic, antiviral, anti-inflamation and anti-allergy. The objective of this study is to assessed antiviral activity of C. ramiflora Linn leaves extract against DENV-2 in-vitro. The potency of C. ramiflora Linn leaves extract at concentration of 1.25; 2.5; 5; 10 and 20 μg/ml towards DENV was performed on Huh 7.5 cell infected by DENV-2 with moi of 0.5. Each treatment was repeated 6 times compared with DMSO treated and infected DENV-2 cells as control. Inhibition rate of the extract against DENV replication was measured using foci-forming immunoassay. Statistically, administration of C. ramiflora Linn leaves extract at 1,25 ; 2,5 ;5 ; 10 and 20 μg/ml resulting 36,06 %, 45,96 %, 47,35%, 55,94%, 62,70% inhibition towards DENV-2 respectively, with significant value (p < 0,05). This result showed that the extract of C. ramiflora Linn leaves has potency as anti-dengue.

Antiviral Activity of Cynometra ramiflora Linn Leaves Extract Against Replication of Dengue Virus Serotype 2 on Huh 7.5 Cell In Vitro