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Ciplukan (Physalis angulata L) and roselle petals (Hibiscus sabdariffa L) have been shown to have blood sugar levels decreasing properties. This study aims to determine the effect of the Ciplukan and Roselle petals ethanol extract combination to the decrease in blood sugar levels in alloxan-induced diabetic rats (Sprague Dawley). The diabetic rats were divided into seven groups, each consisting of four rats. Group I (negative control), group II (positive control), group III (ciplukan 10mg/200g BW), group IV (roselle petals 60mg/200g BW), group V (ciplukan 5mg/200g BW and roselle petals 30mg/200g BW), group VI (ciplukan 5mg/200g BW and roselle petals 60mg/200g BW) and group VII (ciplukan 10mg/200g BW and rosella petals 30mg/200g BW). All groups were induced with alloxan. Parameters observed were decreased blood sugar levels on the 15th and 30th day. After that, surgery and histopathological observation of pancreatic organs were conducted at the 31st day. Blood sugar percentage was analysed using one-way ANOVA with 95% significance level and continued with the Tukey test. The results showed that group number VII combination of 70% ethanol extract ciplukan with 10mg/200g BW dose and roselle flower petal dose 30mg/200 g BW decreased blood sugar level equal to glibenclamide dose 0.052mg/200g BW (p≥0.05) that is equal to 66.74% and improvement activity of pancreatic islets of Langerhans, has been shown at the

Study in Activity Combination of Physalis angulata and Hibiscus sabdariffa in 70% Ethanol Extract to Decrease Blood Sugar Levels and Histopathology of Pancreas Langerhans Island in Alloxan Induced Diabetic Rats