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The article presents the pilot functional neuroimaging study results of the treatment process by means neuro-electrostimulator SYMPATHOCOR-01 in patients with depressive disorder. The study involved three patients. The changes in the brain's default mode network (DMN) as a result of neuro-electrostimulation course are demonstrated. Along with clinical improvement (HDRS-21 and BDI-II scales), changes in DMN's performance from neuroimaging data are shown. An increase in the medial prefrontal cortex and cingulate gyrus functional connection activity with various parts of the brain was noted. These changes indicate the activation of neuroplasticity processes and restoring the work of DMN in patients with depression.

Application of Multichannel Electrical Stimulation of the Neck Nervous Structures in Patients with Depressive Disorders: An fMRI Case Study