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. Annual parasite incidence (API) in East Nusa Tenggara Province (NTT) 2015 per 1000 population is 7.04%. However, API in each Public Health Center (Puskesmas) Sumba Island remains high. High levels of pro-inflammatory cytokines in malaria infection, such as TNF-α is associated with severe pathology, whereas, anti-inflammatory cytokines such as IL-10 is associated with acute malaria. The objective of the study was to analyze correlation between parasite densities and plasma level of both cytokines in P. vivax-infected patients in East Sumba Regency East Nusa Tenggara Province. Methods. Parasite densities were calculated per 500 leucocytes on Giemsa-stained thick blood smears. The levels of TNF-α and IL-10 were measured by Enzyme-Linked Immunosorbent Assay (ELISA) method. Statistical analyses were done by Spearman test. Results. Correlation was observed significantly in parasite density and TNF-α p = 0.032 and parasite density and IL-10 p=0.000. This result indicated that the stage of immunity in patients was not affected by the parasite density but clinical symptoms may have a greater role in increasing and decreasing the plasma level of cytokines. Conclusion. There was correlation between parasite densities and plasma level of TNF-α and IL-10 in P. vivax infected patients is the studied areas.

proceedings of the 2nd international conference postgraduate school

Correlation of Parasite Density with Plasma Level of TNF-α and IL-10 in Patients Infected by Plasmodium Vivax in East Sumba District, East Nusa Tenggara Province