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Postsurgical complication of hypertension may occur in cardiac patients. To decrease the chances of complication it is necessary to lower high blood pressure as soon as possible. Continuous infusion of vasodilator drugs, such as sodium nitroprusside (Nipride), would quickly lower the blood pressure in most patients. However, each patient has a different sensitivity to infusion of Nipride. The parameters and the time delays of the blood pressure control system are initially unknown. Moreover, the parameters of the transfer function associated with a particular patient change over time. The objective of the study is to develop a procedure for blood pressure control in the presence of uncertainty of parameters and considerable time delays. In this paper, a sensitivity analysis was performed, changing the parameter that controls the convergence rate of weight factors (V). The simulation results showed significant changes in settling time (Ts), stressing the importance of this parameter on the control model definition. Considering a V = 0.05 was obtained Ts = 195s and, for same patient, Ts = 510s by increasing the value to V = 0.4, with the Root Mean Square Error (RMSE) varying but always lower than 1%.

Parametric Sensitivity Analysis of a Multiple Model Adaptive Predictive Control for Regulation of Mean Arterial Blood Pressure