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In order to build a multimodal nonlinear endomicroscope to image brain border during operation, our group is building an optical database on brain biopsy tissues analysis collected with excitation panning from deep UV to near infrared. This paper focuses on the results from deep UV excitation of endogenous fluorescence from glioblastoma and control human brain samples. The samples were imaged and spectrally analysed. The excitation wavelengths were tuned from 275 nm to 340 nm. Two promising indicators to discriminate tumorous tissue from the control were found. A preliminary correspondence between fluorescence images and histological H&E staining open a huge door to confirm results with a medical expertise.

Endogenous Fluorescence Analysis under Deep UV Excitation to Discriminate Human Brain Tumor Tissue - Difference between Glioblastoma and Healthy Control Tissue