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This paper describes an ambulatory monitor for beat-by-beat monitoring of systolic blood pressure (SBP) based on an ASIC chip and a mobile phone. The ASIC is able to measure electrocardiogram (ECG), photoelectric plethysmogram (PPG), and has a peripheral interface to control an air pump and valve for inflating and deflating a sphygmomanometer cuff in conventional blood pressure measurement. Algorithms for signal processing, characteristic point detection and SBP estimation are implemented on a mobile phone. Pulse arrival time (PAT) is derived from the apex of QRS complex to the maximum slope of PPG, and is used to estimate a rapid change component in SBP beat-by-beat. An oscillometric sphygmomanometer with a cuff is used to determine SBP intermittently for calibration purpose. Data communication between a mobile phone and the ambulatory monitor is conducted via a Bluetooth wireless connection. Performance of the prototype is examined by data from five healthy college students. The results show that 65.9% of estimated SBP fall into ±5% relative error, 96.6% in ±10% and 99.7% in ±15%. This prototype is a pilot study aiming at integrating an innovative sphygmomanometry into a mobile phone for continuous blood pressure monitoring. We expect to find potential applications in ambulatory monitoring and daily

Beat-by-Beat Monitoring of Systolic Blood Pressure based on an ASIC and a Mobile Phone for Ambulatory Application