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Locating signals for the initiation of gene expression in DNA sequences is an important unsolved problem in genetics. Over more than two decades researchers have applied a large variety of sophisticated computational techniques in order to address it, but only with moderate success. In this paper we investigate the reasons for the relatively poor performance of the current models, and outline some possible directions for future work in

ON THE FUTILITY OF INTERPRETING OVER-REPRESENTATION OF MOTIFS IN GENOMIC SEQUENCES AS FUNCTIONAL SIGNALS