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Colorectal cancer (CRC) screening using stool DNA was recently found to yield good detection rates. A multi-target stool DNA test (Cologuard®, Exact Sciences), including methylated genes has been recently approved by the U.S. Food and Drug Administration. The aim of this study was to validate these aberrantly methylated genes as stool-based DNA markers for detecting CRC and colorectal advanced adenoma (AA) in the Korean population.

intestinal research/intestinal research

Is methylation analysis ofSFRP2,TFPI2,NDRG4, andBMP3promoters suitable for colorectal cancer screening in the Korean population?