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Calprotectin is a heterodimer of the calcium binding proteins S100A8 and S100A9, and is mainly present in neutrophils.1 Fecal calprotectin levels are correlated with the degree of intestinal inflammation, and have been found to increase when neutrophils migrate into the bowel lumen due to the inflammatory process.2 Therefore, fecal calprotectin could help discriminate between IBD and IBS,3 monitor treatment response and endoscopic disease activity,4,5 and predict relapse for IBD.6 Studies have also shown that fecal calprotectin levels are correlated with endoscopic severity scores5 and the extent of inflammation in Asian patients with UC.7 Coupled with the fact that it is a non-invasive and easily accessible test, the use of fecal calprotectin tests is expected to rise.

Could fecal calprotectin enter mainstream use for diagnosing and monitoring inflammatory bowel disease?