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Toxoplasma gondii is the most common protozoan found in animals and humans and has been found in several of the host’s organs, including the liver. This study aimed to evaluate hepatic injury in experimental toxoplasmosis caused by two strains of T. gondii (RH and Me-49 strains). Biochemical and histopathological analyses were performed. It was possible to detect significant increases in serum levels of AST, ALT and LDH in both infections. The histopathological analysis showed inflammatory infiltration in the Me-49 strain infection and hyperemia and vasodilation in the RH strain infection. The acute infection (RH strain) induced hepatic failure and the death of the host. The chronic infection (ME-49 strain) caused liver damage but not enough to kill the host. Therefore this study validates the importance of biochemical concentrations for the evaluation of the infection, showing the importance of rigorous clinical assessment of T. gondii infected individuals.

EXPERIMENTAL TOXOPLASMOSIS: EVALUATION OF THE HEPATIC DAMAGE IN MURINES