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Leprosy is a chronic disease caused by Mycobacterium leprae, an obligatory intracellular bacillus that infects preferentially skin macrophages and Schwann cells of peripheral nerves. The diagnosis of the disease is complex as there are several clinical manifestations. New diagnostic tests aiming the control of disease transmission are being pursued, among which we highlight the dosage of IgM anti phenolic glycolipid-1 (PGL-1). Total serum antibodies against PGL-1 in patients and in their household contacts were evaluated by enzyme immunoassay. Both patients and their contacts presented detectable levels of anti-PGL-1 in the serum thus indicating a potential risk of transmission of the disease among these individuals.

revista de patologia tropical / journal of tropical pathology

AVALIAÇÃO DOS ANTICORPOS SÉRICOS TOTAIS ANTIGLICOLIPÍDEO FENÓLICO DE Mycobacterium leprae EM INDIVÍDUOS PORTA DORES DE HANSENÍASE E SEUS CONTATOS DOMICILIARES NO ESTADO DE GOIÁS, BRASIL