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Neurochemical and behavioral studies in different brain areas were realized in adult rats (2 months- old) that presented seizures and status epilepticus (SE), induced by pilocarpine (400mg/kg, sc, P400), with the aim of investigate the activities of enzymes superoxide dismutase (SOD) and catalase (CAT) during the acute phase (1 and 24) of convulsive process. The behavioral studies in adult animals showed that the administration of P400 produced signs cholinergic peripherals and stereotyped movements in all animals in the two periods of observation. The animals observed by 1h showed similar behaviour to the group of 24, only that the rate of development of seizures, SE, was slightly reduced, and there was no death. The neurochemical studies revealed that the SOD activity increased during the first hour in all the areas. In the period 24 hours increased only in frontal cortex. In catalase activity in both periods and in areas studied there was a significant increase. Our results indicate that the seizures induced by pilocarpine have behavioural change characteristics of epileptic activity and there may also be a considerable increase in the activities of antioxidant defenses studied, in an attempt to protect the animal against neuronal damage produced by oxidative stress observed in brain structures studied. The behavioural change and the activities of SOD and CAT observed suggests an extensive participation of the hippocampus, striatum and the frontal cortex of adult rats at the installation, propagation and/or maintenance of convulsive process induced by pilocarpine.

ALTERAÇÕES COMPORTAMENTAIS E NEUROQUÍMICAS DURANTE A FASE AGUDA DO PROCESSO CONVULSIVO INDUZIDO POR PILOCARPINA