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Alpha1 (α1)-adrenoceptor antagonists are widely used to treat lower urinary tract symptoms. These drugs not only act on peripheral tissues, but also cross the blood-brain barrier and affect the central nervous system. Therefore, α1-adrenoceptor antagonists may enhance brain functions. In the present study, we investigated the effects of tamsulosin, an α1-adrenoceptor antagonist, on short-term memory, as well as spatial learning and memory, in rats.

international neurourology journal

Alpha&amp;lt;sub&amp;gt;1&amp;lt;/sub&amp;gt;-Adrenoceptor Antagonists Improve Memory by Activating &amp;lt;i&amp;gt;N&amp;lt;/i&amp;gt;-Methyl-D-Aspartate-Induced Ion Currents in the Rat Hippocampus