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Alcohol dependence is a debilitating disorder with current therapies displaying limited efficacy and/or compliance. This thesis investigated the contribution of two key neurotransmitters; noradrenaline and serotonin in alcohol dependence using a mouse model of binge-like alcohol consumption. Using this model, the study demonstrated that long-term alcohol intake causes neuroadaptive changes in the signalling of these molecules leading to alterations in normal emotional states and alcohol dependence. Finally, the thesis highlighted the efficacy of the FDA approved drug for hypertension pindolol and the anxiolytic drug tandospirone to reduce alcohol consumption, thereby offering a novel approach to improve treatments for alcohol addiction

Serotonin and Noradrenaline Signalling in Binge-Like Long-Term Alcohol Intake and Associated Maladaptive Effects in Adult Mice