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This thesis conducted in-depth exploration of the aetiology of basal cell carcinoma (BCC) according to the anatomic site on which the tumour arises. It compared phenotypic characteristics, environmental and genetic risk factors, between people who develop incident BCCs on habitually sun-protected body sites (trunk) and those who had only ever had BCCs on habitually sun-exposed sites (head). The findings suggested that the pathophysiology of BCC differs between lesions arising on different anatomic sites and subtypes. Truncal BCCs arise because of relatively low dose cumulative UVR exposure of the trunk in people who have had a greater opportunity for truncal exposure

Environmental, Phenotypic and Genetic Risk Factors for Basal Cell Carcinoma of the Skin Arising at Different Body Sites