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The hydrogeological schematisation of the multi-layered stratigraphical sequence and the results of groundwater flow modelling by MODFLOW code for the Quaternary aquifer system of the south-eastern part of Lithuania have been discussed in the paper. The regional groundwater steady-state flow model has been calibrated applying hydrochemical and isotope data. A tritium isotope data set for groundwater in upland, transit and lowland sites has been used to identify the flow model for water residence time.

The Quaternary aquifer system flow model by chemical and tritium isotope data: case of south-east Lithuania