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Six dogs each with open and closed-cervix pyometra (Group I and II) were medicallymanaged with mifepristone @ 2.5mg/kg body weight orally twice daily for five days, followed bycloprostenol @ 5?g/kg body weight subcutaneously on every alternate day after ensuring cervicalpatency, till complete evacuation of uterus was assessed by ultrasonography. Haematological andserum biochemical values were estimated on the day of presentation. The treatment responsewas assessed by reviewing both haematological and serum biochemical values further on days3, 7, 14 and 21 of treatment. The mean total erythrocyte count (TEC), haemoglobin concentrationand volume of packed red cells (VPRC) were significantly lower and mean total leucocyte count(TLC) was significantly higher in all animals of both groups during the day of presentation. Thevalues significantly improved after initiation of treatment. Total thrombocyte count, serum totalprotein, albumin, BUN and serum creatinine levels were within the normal range. TEC, TLC, Hbconcentration, VPRC could be used for prognostic markers of treatment evaluation in caninepyometra.

Haemato-biochemical studies in medically managed open and closed-cervix pyometra in dogs