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One of the most serious complications of diabetes is the formation of Diabetic Foot Syndrome. Herbal extracts that combine high antioxidant and antimicrobial properties can be used to treat the resulting neuropathy.  The aim of this study was to determine antimicrobial and antioxidant activities of crude extracts isolated from plants growing in Kazakhstan, which could be used to develop products for treatment of Diabetic Foot Syndrome.    Method  Different solvents, including dichloromethane and ethanol, were used to prepare plant extracts. The crude extracts from the plants were tested for antimicrobial activity using a modified version of the CLSI/NCCLS methods. All organisms were obtained from American Type Culture Collection. These included the fungi  Candida glabrata  ATTC 90030, the bacteria  Staphylococcus aureus  ATCC 29213, and  Methicillin-resistant S. aureus  ATCC 43300. The 2,2-diphеnyl-1-picrylhydrazyl (DPPH) assay, 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radical scavenging assay were used to analyzed the antioxidant capacity.    Results  The results clearly indicate that antibacterial and antifungal activities vary with plant species. Dichloromethane extracts produced favorable results in all assays.  Epilobium hirsutum, Rhodiola quadrifida, Rumex confertus  showed antifungal activity against  Candida glabrata  in all extracts where IC 50  less than 3 μg/ml.  Rumex confertus, Glycyrrhiza Uralensis and Vexibia alopecuroides  showed anti-fungal activity against  Staphylococcus aureus  (IC 50  =10.80 μg/ml), (IC 50  =11.10 μg/ml), (IC 50  =3.05 μg/ml) and  Methicillin-resistant S. aureus  (IC 50  =16.20 μg/ml), (IC 50  =11.00 μg/ml), (IC 50  =2.90 μg/ml) respectively. In spite of this,  Vexibia alopecuroides  extract showed no antioxidant activity. The other extracts showed a dose dependent ABTS scavenging activity. IC 50  values were for the following: 6.6 μg/ml  Epilobium hirsutum;  4.5 μg/ml  Rumex confertus;  3.8 μg/ml  Rhodiola quadrifida,  5.7 μg/ml  Glycyrrhiza Uralensis.  Extracts of  Epilobium hirsutum  and  Rumex confertus  had high antioxidant activity greater than 85% inhibition of DPPH (P ≤ 0.05).    Conclusion  The demonstrated antimicrobial and antioxidant activities showed evidence supporting the use of herbal extracts to treat Diabetic Foot Syndrome.

Herbal extracts in the treatment of Diabetic Foot Syndrome