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The increasing prevalence of chronic autoimmune-mediated inflammatory disorders (AIMIDs)in aging human populations creates a high unmet need for safe andeffective medications. However, thus far the translation of pathogenicconcepts developed in animal models into effective treatments for thepatient has been notoriously difficult. The main reason is that currentlyused mouse-based animal models for the pipeline selection of promising newtreatments were insufficiently predictive for clinical success. Regardingthe high immunological similarity between human and non-human primates (NHPs),AIMID models in NHPs can help to bridge the translational gap betweenrodent and man. Here we will review the preclinical relevance of theexperimental autoimmune encephalomyelitis (EAE) model in common marmosets(<i>Callithrix jacchus</i>), a small-bodied neotropical primate. EAE is a generic AIMID modelprojected on the human autoimmune neuro-inflammatory disease multiplesclerosis (MS)

primate biology/primate biology

The common marmoset (&amp;lt;i&amp;gt;Callithrix jacchus&amp;lt;/i&amp;gt;): a relevant preclinical model of human (auto)immune-mediated inflammatory disease of the brain