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. The capability of ambient particles to generate in vivo reactiveoxygen species (ROS), called oxidative potential (OP), is a potential metricfor evaluating the health effects of particulate matter (PM) and issupported by several recent epidemiological investigations. Studies usingvarious types of OP assays differ in their sensitivities to varying PMchemical components. In this study, we systematically compared twohealth-relevant acellular OP assays that track the depletion of antioxidantsor reductant surrogates: (i) the synthetic respiratory-tract lining fluid (RTLF)assay that tracks the depletion of ascorbic acid (AA) and glutathione (GSH)and (ii) the dithiothreitol (DTT) assay that tracks the depletion of DTT.Yearlong daily samples were collected at an urban site in Atlanta, GA(Jefferson Street), during 2017, and both DTT and RTLF assays were performedto measure the OP of water-soluble PM2.5 components. PM2.5 massand major chemical components, including metals, ions, and organic andelemental carbon were also analyzed. Correlation analysis found that OP asmeasured by the DTT and AA depletion (OPDTT and OPAA,respectively) were correlated with both organics and some water-solublemetal species, whereas that from the GSH depletion (OPGSH) wasexclusively sensitive to water-soluble Cu. These OP assays were moderatelycorrelated with each other due to the common contribution from metal ions.OPDTT and OPAA were moderately correlated with PM2.5 masswith Pearson's r=0.55 and 0.56, respectively, whereas OPGSHexhibited a lower correlation (r=0.24). There was little seasonalvariation in the OP levels for all assays due to the weak seasonality ofOP-associated species. Multivariate linear regression models were developedto predict OP measures from the particle composition data. Variability inOPDTT and OPAA were not only attributed to the concentrations ofmetal ions (mainly Fe and Cu) and organic compounds but also to antagonisticmetal–organic and metal–metal interactions. OPGSH was sensitive tothe change in water-soluble Cu and brown carbon (BrC), a proxy for ambienthumic-like substances.

Characterization and comparison of PM&lt;sub&gt;2.5&lt;/sub&gt; oxidative potential assessed by two acellular assays

Characterization and comparison of PM<sub>2.5</sub> oxidative potential assessed by two acellular assays