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AT motif binding factor 1 (ATBF1) gene can promote the expression level of the growth hormone 1 (GH1) gene bybinding to the enhancers of the POU1F1 and PROP1 genes; thus, it affects the growth anddevelopment of livestock. Considering that the ATBF1 gene also has a closerelationship with the Janus kinase–signal transductor and activator of transcription (JAK–STAT) pathway, the objective of this work was toidentify novel single-nucleotide polymorphism (SNP) variations and theirassociation with growth traits in native Chinese cattle breeds. Five novelSNPs within the ATBF1 gene were found in 644 Qinchuan and Jinnan cattle for first time using 25 pairs of screening and genotypingprimers. The five novel SNPs were named as AC_000175:g.140344C>G (SNP1), g.146573T>C (SNP2),g.205468C>T (SNP3), g.205575A>G (SNP4) andg.297690C<T (SNP5). Among them, SNP1 and SNP2 were synonymouscoding SNPs, while SNP5 was a missense coding SNP, and the other SNPs wereintronic. Haplotype analysis found 18 haplotypes in the two breeds,and three and five closely linked loci were revealed in Qinchuan and Jinnanbreeds, respectively. Association analysis revealed that SNP1 wassignificantly associated with the height across the hip in Qinchuan cattle. SNP2 was found to be significantly related to chest circumference and body sidelength traits in Jinnan cattle. SNP3 was found to have significantassociations with four growth traits in Qinchuan cattle. Moreover, thedifferent combined genotypes, SNP1–SNP3, SNP1–SNP4 and SNP2–SNP5 weresignificantly associated with the growth traits in cattle. These findingsindicated that the bovine ATBF1 gene had marked effects on growth traits, and thegrowth-trait-related loci can be used as DNA markers for maker-assisted selection (MAS) breedingprograms in cattle

archives animal breeding/archiv für tierzucht

Evaluation of novel SNPs and haplotypes within the &amp;lt;i&amp;gt;ATBF1&amp;lt;/i&amp;gt; gene and their effects on economically important production traits in cattle