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Visfatin, an adipokine hormone produced primarily by visceral adipose tissuein mammals, has been identified as having a crucial role in growth and developmentof skeletal muscle and lipids. In this research, the effects of two indelloci (35 bp indel: AC_000161.1: g. 20540–20541 InsACTGGAATTCTAGTTTTTGCTACTAATGAA located in intron 4; 6 bp indel:AC_000161.1: g. 25873–25878 Del: T located in intron 5)of the visfatin gene on mRNA expression levels were studied by means of real-time quantitativePCR (qPCR) in longissimus muscle and subcutaneous fat from 95 Qinchuancattle. Firstly, visfatin expression level in longissimus muscle of fetal cattle wasprominently greater than that in calves and adult cattle (P < 0.05).The expression level of visfatin in subcutaneous fat was notably higher than that inlongissimus muscle of calves and adult cattle (P < 0.05). Secondly,there were three genotypes (ins/ins, del/del and ins/del) and two genotypes(ins/del and ins/ins) detected in the 35 bp locus and 6 bp locus, respectively.Visfatin showed a minimum expression level in longissimus muscle in the homozygousdeletion genotype at the 35 bp indel locus. Especially in calves, expression ofvisfatin was significantly greater in the heterozygous genotype than that inthe homozygous insertion genotpye (P < 0.05). No statisticaldifferences were found among visfatin expression level based on genotypes in the 6 bpindel locus (P > 0.05). Compared to heterozygous genotype, theexpression level of homozygous insertion genotype was lower in longissimusmuscle but greater in subcutaneous fat. These results imply that theexpression levels of bovine visfatin vary with age and its indels might beputative variants mediating the expression of the bovine visfatin gene. This study provides useful information for further functional studies of bovinevisfatin

Indels within the bovine visfatin gene affect its mRNA expression in longissimus muscle and subcutaneous fat