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The major histocompatibility complex (MHC) plays a crucial role in theprocessing and presentation of antigens and in discrimination between selfand non-self. The aim of this investigation was to scrutinize the structuraldiversity and possible duplication of the MHC-DQA genes in yak(Bos grunniens). Two cDNA sequences were amplified and designated asBogr-DQA1 (DQA*0101) and Bogr-DQA2(DQA*2001) with GenBank accession numbers JQ864314 and JQ864315,respectively. The nucleotide and amino acid sequence alignment betweenBogr-DQA1 and Bogr-DQA2 molecules showed that these two identifiedMHC-DQA gene sequences had more similarity to alleles of specificDQA1 and DQA2 genes from other Ruminantia species than toeach other. The result from phylogenic investigation also revealed that therewas a larger genetic distance between these two genes than between homologousgenes from different species. The presence of different bovine DQA putativemotifs and the large genetic distance between Bogr-DQA1 and Bogr-DQA2 suggestthat these sequences are non-allelic. Further, these results indicate thatDQA gene duplication occurs in ruminants. This study will be helpfulin knowing MHC diversity in common ruminants and will deepen ourunderstanding of the variation of immunological functions, evolutionaryconstraints, and selective forces that affect MHC variation within andbetween species

Cloning and characterization of MHC-DQA1 and MHC-DQA2 molecules from yak (&lt;i&gt;Bos grunniens&lt;/i&gt;)

Cloning and characterization of MHC-DQA1 and MHC-DQA2 molecules from yak (<i>Bos grunniens</i>)