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Magnesium is the fourth most abundant mineral element in vertebrates and thesecond most common intracellular cation. Recently identifiedMg<sup>2+</sup>-specific channels – TRPM6 and TRPM7 – have been shown to beessential for whole-body and cellular Mg<sup>2+</sup> homeostasis. The aim of thestudy was to determine the effect of inulin on the expression of TRPM6 andTRPM7 in the renal cortex and medulla of growing pigs. The study was carriedout on 16 Danbred  ×  Duroc castrated male piglets fed a cereal-baseddiet without inulin or with 2 % addition of inulin from chicory root fromthe 10th day of life. In pigs fed a diet with inulin, TRPM6 expression wasgreater in both the renal cortex and medulla compared to the control group.The expression of TRPM7 in both the renal cortex and medulla in the controlgroup and in piglets fed a diet enriched with inulin was relatively stable.To our knowledge, this is the first study aimed at the identification ofTRPM6 and TRPM7 in the kidneys of pig. It is proposed that inulin addition tofodder resulted not only in a magnesium absorption increase, but also, due toprolonged low plasma Mg concentration of examined piglets, renal magnesiumretention. Therefore, higher magnesium reabsorption via increased TRPM6expression in the kidney was probably observed in order to supplementdeficiencies of this element. Diet-unresponsive expression of TRPM7 supportsthe concept that this channel is not involved in the extracellular magnesiumhomeostasis

Identification of TRPM6 and TRPM7 expression changes in response to a diet supplemented with inulin in porcine kidney