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In the present study, the polymorphisms of gonadotropin-releasing hormone receptor(GnRHR) gene were analysed as a genetic marker candidate for litter size in 720 individualsfrom Shaanan goats (SG) and Boer goats (BG). Two alleles (A and C), two observed genotypes(AA and AC), and single nucleotide polymorphisms (SNPs) were detected. The frequencies ofalleles A and C in two goat breeds were 0.78–0.82 and 0.18–0.22, respectively. The SNP locuswas in Hardy–Weinberg disequilibrium in two goat breeds (P<0.05). In addition, comparisonsbetween the nucleotide sequences of AA and AC genotypes showed one mutation (T>A) atexon 2. The results showed that AA genotype was associated with better litter size in SG andBG breeds. Therefore, these results suggest that GnRHR gene is a strong candidate gene thataffects litter size in goats

Novel single nucleotide polymorphisms of &lt;i&gt;GnRHR&lt;/i&gt; gene and their association with litter size in goats

Novel single nucleotide polymorphisms of <i>GnRHR</i> gene and their association with litter size in goats