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Monodispersed Chitosan microspheres containing butyric acid were prepared to develop drug carriers for colitis ulcerosa. The chitosan microspheres as carriers were prepared using SPG (Shirasu Porous Glass) membrane emulsification to examine the effect of preparation conditions (chitosan and sodium chloride concentrations and the pore size of SPG) on the physicochemical properties(specific surface area, porosity and density) of the microspheres. After the monodispersed w/o emulsion of organic acid solutions of chitosan was prepared, the monodispersed chitosan microspheres were obtained by concentrating chitosan droplets in the emulsion with the w/o emulsion containing a high concentration of sodium chloride. The monodispersed chitosan microspheres with the arbitrary size, diameter and porosity could be easily prepared by selecting experimental conditions according to the purposes. The release of butyric acid from the chitosan microspheres was measured under various conditions to determine the most suitable release condition of butyric acid into the large intestine in vitro at 309 K.

Preparation of Monodispersed Chitosan Micropheres Using SPG Membrane Emulsification and Its Application as Drug Carriers