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This study was designed to evaluate haematological response between Nigerian indigenous pigs (NIP) and Large White x Landrace crossbred pigs (LWL) when vaccinated with sheep RBC. Twenty male pigs with average age of 42 ± 3 days and weighed 3.10 ± 0.29 kg (NIP) and 6.90 ± 0.43 kg (LWL), were used. They were assigned to groups A (10 NIP) and B (10 LWL); each was further divided into two with five animals in each replicate. Processing of sheep RBC followed standard procedures; feed and animal management were similar. All the pigs were vaccinated with1 ml of 10 % sheep RBC per pig at week 4 and revaccinated 3 weeks later. Their haematological profiles were determined using standard procedures and the study lasted ten weeks. There was a rise in WBC count of both groups after initial vaccination. Mean WBC count of LWL was significantly (p ≤ 0.05) higher at weeks 0, 1, 4 and 6, respectively. Lymphocyte count of the two groups also increased sharply after initial vaccination; values recorded for LWL showed a slight but a continuous rise while those of the NIP generally decreased and increased in value. A significant differences in mean values of neutrophil were recorded prior to initial vaccination (p = 0.011, t = 8), on weeks 1 (p = 0.013, t = 8) and 3(p = 0.005, t = 8) with NIP maintaining higher values than LWL. There was no significance (p ≥0.05) difference in the mean values of eosinophil, basophil and monocytes for both groups. Introduction Swine and poultry have made significant contributions to the provision of animal protein in many countries (Eze et al., 2010; Abonyi et al., 2014). According to Oluwole and Omitogun (2016), the pig plays major functions in socioeconomic life of man: it serves as source of income; it is used in fulfilling somecultural rites and contributes to food security of the rural populace. They can be reared under a variety of production systems; ranging from simple backyard pigs living on scavenger belts, to fairly operated firms, to large integrated pig industries with sophisticated biosecurity (Holnes, 1991). Whereas most exotic pigs

Comparative evaluation of haematological profile of the Nigerian indigenous and Large White x Landrace crossbred pigs vaccinated with sheep RBC