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There have been studied factors of metabolic syndrome, risk of development of type 2 diabetes on test-questionnaire FINDRISK, and parameters of intracellular metabolism of neutrophils in 94 men (mean age 47.7 ± 7.4 years) without ischemic heart disease. Increased risk of developing type 2 diabetes in patients with metabolic syndrome was accompanied by growth activity of myeloperoxidase and contents of hydrogen peroxide in neutrophils, and also increased body mass index. In patients with expressed obesity III, the growth level of oxygen-dependent metabolism of neutrophils was observed on the background of decreasing antioxidant defence in phagocytes that can promote the development of oxidative stress.

Activity of Intracellular Metabolism at Neutrophils in Patients with Metabolic Syndrome