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Several studies indicate that interleukin-1 receptor antagonist (IL-1ra) is an important regulator of host immunity and play a key role in cancers development. Some of these studies have shown a potential role of a variable number of tandem repeat (VNTR) of 86 bp polymorphism within IL-1ra gene (IL-1RN) in host immune response variability. We investigated what VNTR polymorphism involves in susceptibility to ovarian cancer in Tunisia with a case control study. VNTR polymorphism within IL-1RN gene is genotyped by a simple PCR and agarose gel electrophoresis in 257 healthy women and 55 women with ovarian cancer. Our results indicated that allele 1 is associated with an increased susceptibility to ovarian cancer development (p=0.009; OR: 1.95, 95% CI, 1.14-3.36) and in the histological grading in Tunisian women. However, allele 3 seems to play a protective role (p=0.018; OR: 1.95, 95% CI, 0, 00-0.73). There were no significant differences between IL-1ra polymorphism alleles and tumor stage (International Federation of Gynecology and Obstetrics) but the allele 1 is significantly associated with histological grading in Tunisian women. The allele 1 of the IL-1RN seems to play a role in histological grading and susceptibility to ovarian cancer but it’s not associated with disease progression. Nevertheless, the risk for developing ovarian cancer is decreased by the presence of allele 3.

Interleukin-1 Receptor Antagonist VNTR Polymorphism and Ovarian Cancer Susceptibility in Tunisian Women