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Tetrahydroquinazoline and sulfonamide are two very important class of heterocycles, showing a wide spectrum of biological and biochemical activities on the one hand. On the other hand, there is a growing demand of new pharmacophore, which can truly replace the old resistant marketed drug. Consequently we are interested in synthesizing new molecules containing hybrid scaffold having both the tetrahydroquinazoline and sulfonamide moiety, as both are very active pharmacophore. In the present communication, sulphonamide derived tetrahydroquinazoline heterocyclic rings have been synthesized by using intramolecular cyclization reaction. Using this methodology, a small library of ten compounds has been synthesized. The structure of the compound was unambiguously resolved by the single X-ray crystal structure of some of the molecules. A highly substituted heterocycles can be easily synthesized by this methodology. Moreover these new sulfonamide derived tetrahydroquinazoline compounds may act as very potent inhibitors of different enzymes or proteins, responsible for many diseases.

Synthesis of Sulfonamide Derived from New Tetrahydroquinazoline Derivatives via Intramolecular cyclization