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Objective : Serotonin selective re-uptake inhibitors (SSRI) are well-known antidepressants. There has been no report on the different benefits that different SSRIs may confer on tinnitus patients. We conducted a retrospective chart review comparison study of the clinical effect of 2 different SSRIs (paroxetine, fluvoxamine) on tinnitus patients. Methods : Fluvoxamine was prescribed to 26 cases (defined as group F), and paroxetine to 33 patients (defined as group P). We evaluated depression and tinnitus severity with questionnaires. We evaluated the clinical effect with the Clinical Global ImpressionImprovement scale (CGI-I). Results : The imipramine equivalence of the prescribed paroxetine was 92.6 ± 24.5 and that for fluvoxamine was 81.4 ± 29.3.We determined no statistical difference in each value between the groups. There was statically significant deference in THI before and after the treatment in both group P (P<0.05) and group F (P<0.05). The CGI-I scale scores were 2.5 ± 1.3, and 2.9 ± 1.2 for group F and group P, respectively. Both SSRIs were equally effective to the patients with tinnitus. The CGI-I scale and initial THI were correlated only in paroxetine-treated patients (R = -0.60, P < 0.05). Conclusions : Fluvoxamine and paroxetine affect tinnitus patients differently due to their differing pharmacological effects.

The Effect of two Different Selective Serotonin Reuptake Inhibitors in Patients with Chronic Tinnitus