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Comparative analysis of influenza A (H1N1) pdm09 virus strains isolated in Russian Asia in the pandemic of 2009 and the post-pandemic period of 2011 was carried out. It was shown that pandemic influenza А (H1N1) pdm09 virus strain isolated in the pandemic period is more virulent and able to cause more severe pathological processes in lung tissue of experimentally infected mice compared to the strain А (H1N1) pdm09 isolated in the post-pandemic period. It is probably associated with mutations in genes encoding surface proteins that occurred at the time of influenza A (H1N1) pdm09 virus circulation from 2009 to 2011 and that resulted in emergence of new genetic variants of virus with lower virulence.

journal of virology and microbiology

Comparative Analysis of Biological Properties of Influenza А (Н1N1) pdm09 Virus Strains isolated in the Pandemic of 2009 and the Post-Pandemic Period in the Asian Part of Russia